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Involvement of aberrant chromosome architecture and locus-specific vulnerability to DNA methylation epimutations in bovine large offspring syndrome
(University of Missouri--Columbia, 2022)
are conceived with the use of assisted reproductive technologies (ART; i.e. in vitro oocyte maturation, in vitro fertilization, and embryo culture). Molecular defects reported in both syndromes include global gene misregulation, DNA methylome epimutations...
Effects of supplemental amino acid and grain processing on nutrient disappearance and nitrogen and energy balance in cattle
(University of Missouri--Columbia, 2023)
used in a randomized complete block design. Eighteen calves (295 [plus or minus] 29 kg) and 18 yearlings (521 [plus or minus] 29 kg) were fed either whole, cracked or steam-flaked corn. Total tract starch digestion was greatest for cattle fed steam...
A systems approach to deriving carcass value from Holstein x SimAngus cattle in an accelerated finishing model
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] Beef x dairy has increased in popularity, altering the U.S fed beef supply. The objective of this dissertation was to evaluate the effect of Holstein x SimAngus (Hol x SimAngus) breeding and ...
Improving the value of pigs with severe combined immunodeficiency through novel transplantation
(University of Missouri--Columbia, 2023)
(Swindle et al., 2012, Lossi et al., 2016). Additionally, swine possess higher genetic similarities to humans than mice, and the genetic diversity within pigs better represents a human population than highly inbred mouse strains (Wernersson et al., 2005...
Tracing cat domestication through population genetics and capturing genotype-by environment interactions in US beef cattle genomic predictions
(University of Missouri--Columbia, 2022)
Cat domestication initiated as a symbiotic relationship between wildcats and the peoples of developing agrarian societies in the Fertile Crescent. To refine the sites of cat domestication, over 1,000 random-bred cats of ...
Effects of long-term postgastric infusion of casein or glutamic acid on small intestinal starch digestion, energy balance, body composition, and metabolic fates of luminally assimilated glucose carbon in cattle
(University of Missouri--Columbia, 2022)
Small intestinal starch digestion (SISD) in ruminants is limited, but SISD can be improved by postruminal supply of casein or glutamic acid. There are no reports on the effects of increases in SISD in response to greater postgastric nutrient flows...
The role of mitochondria in early-onset preeclampsia
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] Placental mitochondrial dysfunction may play a role in the etiology of early-onset preeclampsia (EOPE). Mitochondrial function is impaired at term in placentas delivered from EOPE pregnancies, ...
An examination of influenza immunity in pigs and their role in assessing antiviral therapies for humans
(University of Missouri--Columbia, 2022)
The lung is dynamic barrier organ with a complex cell population. Pulmonary immune cells must balance an effective and tolerogenic response to keep homeostasis. Due to numerous similarities to the human respiratory system, ...
Discovery and phenotyping of the determinants and receptors of post-fertilization sperm mitophagy
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] This thesis is concerned with two important aspects of sperm physiology -- mitochondrial health prior to fertilization and mitochondrial inheritance after fertilization. The factors and mechanisms ...
Modulation of bovine preimplantation embryonic development and pregnancy by FGF2, LIF, and IGF1
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 12/1/2024] In vitro embryo production enhances genetic selection through capitalizing on superior genetics, improving fertility, and increasing animal efficiency, all of which contribute to sustainable ...